Too often, immobilization gets overlooked in the early stages of research, when its techno-economic benefits can truly outweigh traditional active-site protein engineering. Well—not any longer.
With this partnership, FabricNano is committed to offering our Predictive Immobilization (PI) plates to assist new and existing Ginkgo customers to build process decisions into the earliest stages of enzyme discovery research. The PI plates are the first statistically-guided approach to immobilization where the relevant factor space is spanned in a simple 96-deep well plate. In a single PI plate, the benefit of 1,000,000 combinatorial immobilization options are collapsed to a set of 96 experiments, all pre-prepared in deep well plate format to help speed up research in the lab.
In addition to our PI plates, FabricNano is also opening up our Interaction Engineering (IE) services to Ginkgo customers that may have already moved months-to-years into enzyme biocatalysis research with limited success in industrial process conditions. This in silico offering is the first-and-only AI guided rational mutagenesis strategy for enzyme surface residues interacting with immobilization carriers. Specifically, FabricNano has taken the concept of sequence-to-function for active site mutagenesis and applied the same principles to sequence-to-immobilization performance. This mutagenesis strategy wouldn’t be available if the team at FabricNano hadn’t built the first dedicated immobilization screening rig on a high-throughput liquid handling robot. Or, if we hadn’t already studied thousands upon thousands of enzyme homologies and enzyme surface mutations in the presence of varying immobilization carriers.